(1-羟环己基)(4-甲氧基苯基)乙腈合成路线 （共 24 条）
反应条件
ammonium hydroxide; nickel monoaluminide in methanol; ethyl acetate
参考文献
Paingankar, Niranjan; Mumbaikar, Vilas; Ekkundi, Vadiraj S; Jalett, Hans-Peter; Siegrist, Urs; Van Der Schaaf, Paul Adriaan; Bienewald, Frank; Studer, Martin; Burkhardt, Stefan
Patent: US2003/114711 A1, 2003 ;
反应条件
hydrogen; Pd-alumina in methanol T=20°C; P=760.051 - 1520.1 Torr; 24 h;
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2008/59525 A2, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
1: H2 / 5percent Rh/Al2O3 / ethanol; aq. NH3 2: 1.) NaHCO3, 2.) LiAlH4 / 1.) CH2Cl2, RT, 20 h, 2.) THF, reflux, 1.5 h View Scheme
参考文献
Yardley; Morris Husbands; Stack; Butch; Bicksler; Moyer; Muth; Andree; Fletcher III; James; Sielecki
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2899 - 2905
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=50°C; P=3750.38 Torr; 10 h;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 27-29 ;
