(1-羟环己基)(4-甲氧基苯基)乙腈合成路线 （共 24 条）
反应条件
hydrogen in isopropyl alcohol T=45 - 55°C; P=7500.75 - 9000.9 Torr;
参考文献
Saravanan, Mohanarangam; Satyanarayana, Bollikonda; Reddy, Padi Pratap
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1392 - 1395
参考文献
American Home Products Corporation
Patent: US4535186 A1, 1985 ;
US 4535186 A
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran T=50°C; P=3750.38 Torr; 10 h;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 27-28 ;
反应条件
1: With hydrogen; acetic acid; palladium on activated carbon in water T=5 - 60°C; P=9000.9 Torr; 2: With sodium hydroxide; water in toluene T=10°C; pH=6.3;
参考文献
PPG-SIPSY
Patent: US2008/125606 A1, 2008 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogen; Pd-alumina in methanol T=20°C; P=760.051 - 1520.1 Torr; 20 h;
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2008/59525 A2, 2008 ;
Location in patent: Page/Page column 15-16 ;
反应条件
hydrogen; platinum on carbon in methanol; water T=40 - 50°C; P=7355.72 - 14711.4 Torr; 10 - 24 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=50°C; P=3750.38 Torr; 10 h;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 27-29 ;
反应条件
1: H2; NH3 / Raney nickel / methanol / 3 h / 35 - 40 °C / 7600 Torr 2: 45 g / methanol; H2O / 3 h / 25 - 30 °C 3: aq. formic acid / 15 h / 90 - 100 °C View Scheme
参考文献
Basappa; Kavitha; Rangappa
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3279 - 3281
反应条件
hydrogen in isopropyl alcohol T=45 - 55°C; P=7500.75 - 9000.9 Torr;
参考文献
Saravanan, Mohanarangam; Satyanarayana, Bollikonda; Reddy, Padi Pratap
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1392 - 1395
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon in methanol; ethanol T=20°C; P=2625.26 Torr; 6 h; Product distribution / selectivity;
参考文献
KRKA
Patent: WO2007/147564 A1, 2007 ;
Location in patent: Page/Page column 12 ;
