N-(7-甲氧基萘-1-基)乙酰胺合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Mentzer; Beaudet
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952 , vol. 234, p. 1692
反应条件
1.1: aq. HCl / 5 h / Heating 2.1: aq. HCl; NaNO2 / 0.5 h / 10 °C 2.2: aq. HBF4 2.3: xylene / 1 h / Heating 3.1: 3.99 g / BBr3 / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
potassium carbonate in acetone
6 h; Heating;
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
potassium carbonate; dimethyl sulfate in acetone
参考文献
Warner-Lambert Company
Patent: US5721234 A1, 1998 ;
参考文献
Bachmann; Horton
Journal of the American Chemical Society, 1947 , vol. 69, p. 58,59
Full Text Show Details
Fierz-David; Blangey; v. Krannichfeldt
Helvetica Chimica Acta, 1947 , vol. 30, p. 816,819
反应条件
1: NaH / dimethylformamide / 1.42 h / 0 - 20 °C
2: 5.41 g / CH2Cl2 / 1.08 h / 0 - 20 °C
View Scheme
参考文献
Scopton, Alex; Kelly, T. Ross
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10004 - 10012
反应条件
1: NaHCO3 (sat) / methanol
2: aq. NaOH / acetone
View Scheme
参考文献
Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374
反应条件
in dichloromethane
T=0 - 20°C; 1.08333 h;
参考文献
Scopton, Alex; Kelly, T. Ross
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10004 - 10012
反应条件
1.1: aq. HCl / 5 h / Heating
2.1: aq. HCl; NaNO2 / 0.5 h / 10 °C
2.2: aq. HBF4
2.3: xylene / 1 h / Heating
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1: aqueous hydrochloric acid
2: aqueous HCl; acetic acid; KI / 80 °C / Diazotization
View Scheme
参考文献
Bachmann; Horton
Journal of the American Chemical Society, 1947 , vol. 69, p. 58,59
