1-苄基-3-(氨甲基)吡咯烷合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 18 h;
参考文献
US2003/236277 A1, ;
Page 26-27 ;
参考文献
US6166015 A1, ;
US 6166015 A
反应条件
1: PPh3; diethyl azodicarboxylate / tetrahydrofuran / 20 °C 2: N2H4*H2O / ethanol / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 11 p. 977 - 989
反应条件
1.1: dichloromethane / 12 h / 0 - 20 °C 2.1: palladium 10 on activated carbon; palladium(II) oxide hydrate; acetic acid; hydrogen / methanol / 48 h / 20 °C 3.1: triethylamine / methanol / 0.5 h / 0 °C 3.2: 24 h / 0 - 20 °C 4.1: sodium hydroxide / methanol; water / 3 h / 20 °C 5.1: 1,2-dichloro-ethane / 18 h 5.2: 18 h View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
反应条件
in diethyl ether; dichloromethane
参考文献
Kadow, John F.; Xue, Qiufen May; Wang, Tao; Zhang, Zhongxing; Meanwell, Nicholas A.
Patent: US2003/236277 A1, 2003 ;
Location in patent: Page 27 ;
反应条件
1: dichloromethane / 12 h / 0 - 20 °C 2: hydrogen / palladium(II) oxide hydrate; palladium 10 on activated carbon / acetic acid; methanol / 48 h / 20 °C 3: triethylamine / methanol / 24 h / 0 - 20 °C 4: sodium hydroxide; water / methanol / 3 h / 20 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
反应条件
in dichloromethane
T=0 - 20°C; 12 h;
参考文献
GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia
Patent: WO2011/56635 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/056635 A1
