1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸合成路线 （共 22 条）
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene T=80°C; 3 h;
参考文献
McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620
反应条件
in pyridine; chloroform
参考文献
Pfizer Inc.
Patent: US4861779 A1, 1989 ;
Title/Abstract Full Text Show Details
Pfizer Inc.
Patent: US4775668 A1, 1988 ;
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene T=80°C; 3 h;
参考文献
McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620
反应条件
in pyridine T=105 - 113°C; 1 h;
参考文献
Egawa; Kataoka; Shibamori; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 181 - 185
反应条件
in pyridine Heating;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
in pyridine 18 h; Heating;
参考文献
Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, p. 983 - 991
参考文献
Bayer Aktiengesellschaft
Patent: US5155223 A1, 1992 ;
参考文献
Korea Institute of Science and Technology
Patent: US5051505 A1, 1991 ;
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene T=80°C; 2 h;
参考文献
McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620
反应条件
in methanol; dimethyl sulfoxide
参考文献
Bayer Aktiengesellschaft
Patent: US4588726 A1, 1986 ;
