1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸合成路线 （共 22 条）
反应条件
sulfuric acid in water; acetic acid 1.5 h; Heating;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
triethanolamine in 1,4-dioxane
反应条件
hydrogenchloride in methanol 8 h; Heating;
参考文献
Hong, Wan Pyo; Lee, Kee-Jung
Synthesis, 2006 , # 6 p. 963 - 968
反应条件
1: t-BuOK / 2-methyl-propan-2-ol 2: aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
1: 31 percent / KF / dimethylsulfoxide / 1 h / 165 °C 2: 95 percent / 10percent aq. HCl / ethanol / 3 h / 120 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, # 1 p. 181 - 185
反应条件
1: 1.) Mg/ethanol, CCl4 / 1.) ethanol, toluene, 1 h, 60-70 deg C; 2.) toluene, 0 to -5 deg C; 12 h, room temperature 2: p-toluenesulfonic acid / H2O / 5 h / Heating 3: acetic anhydride / 2 h / Heating 4: 94 percent / ethanol / 1 h / Ambient temperature 5: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 6: 98 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: acetic anhydride / 2 h / Heating 2: 94 percent / ethanol / 1 h / Ambient temperature 3: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 4: 98 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: 94 percent / ethanol / 1 h / Ambient temperature 2: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 98 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating 2: acetic anhydride / 2 h / Heating 3: 94 percent / ethanol / 1 h / Ambient temperature 4: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 5: 98 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
pyridine in 1,8-diazabicyclo[5.4.0]undec-7-ene
参考文献
Pfizer Inc.
Patent: US4861779 A1, 1989 ;
Title/Abstract Full Text Show Details
Pfizer Inc.
Patent: US4775668 A1, 1988 ;
