3-(氨甲基)苯甲酸甲酯合成路线 （共 14 条）
反应条件
1: With piperidine in DMF (N,N-dimethyl-formamide) T=20°C; 0.5 h; 2: With hydrogenchloride; water 3: With sodium hydrogencarbonate in water
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/80367 A1, 2005 ;
Location in patent: Page/Page column 112 ;
反应条件
1: 100 percent / NaN3 / ethanol / 18 h / Heating 2: 34 percent / PPh3; H2O / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 14 p. 2506 - 2511
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 4.5 h;
参考文献
EP1655283 A1, ;
Page/Page column 16 ;
反应条件
water; triphenylphosphine in tetrahydrofuran T=20°C; 24 h;
参考文献
Okada, Yukihiro; Yokozawa, Masanori; Akiba, Miwa; Oishi, Kazuhiko; O-Kawa, Kyoji; Akeboshi, Tomohiro; Kawamura, Yasuo; Inokuma, Seiichi; Nakamura, Yosuke; Nishimura, Jun
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 14 p. 2506 - 2511
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 16 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 19 p. 4189 - 4206
参考文献
LABORATORIOS MENARINI S.A.
Patent: EP775133 B1, 2001 ;
反应条件
hydrazine in tetrahydrofuran; water Reflux;
参考文献
Cao, Rui; Mueller, Peter; Lippard, Stephen J.
Journal of the American Chemical Society, 2010 , vol. 132, # 49 p. 17366 - 17369
反应条件
thionyl chloride 6 h; Cooling with iceReflux;
参考文献
WO2011/161615 A1, ;
Page/Page column 59 ;
WO 2011/161615 A1
反应条件
1: 42 percent / SOCl2 / 96 h / 20 °C 2: 36 percent / H2 / Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 19 p. 4189 - 4206
反应条件
hydrogenchloride 14 h; Heating;
参考文献
Ashton, Peter R.; Fyfe, Matthew C. T.; Hickingbottom, Sarah K.; Menzer, Stephan; Stoddart, J. Fraser; White, Andrew J. P.; Williams, David J.
Chemistry - A European Journal, 1998 , vol. 4, # 4 p. 577 - 589
