3-(2-甲氧基苯基)-5-甲基-2,3-二氢异恶唑-4-羧酸合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1201 - 1204
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 - 20 °C 2: triethylamine / ethanol; N,N-dimethyl-formamide / 16 h / 20 °C 3: sodium hydroxide / methanol; water / 20 h / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 31 p. 4001 - 4004
反应条件
1: hydroxylamine hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 0 - 20 °C 3: triethylamine / ethanol; N,N-dimethyl-formamide / 16 h / 20 °C 4: sodium hydroxide / methanol; water / 20 h / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 31 p. 4001 - 4004
反应条件
(i), (ii) KOH, aq. EtOH; Multistep reaction;
参考文献
Journal of the Chemical Society, , p. 5845 - 5854
