N-甲基-N-羟乙基苯胺合成路线 （共 41 条）
反应条件
hydrogenchloride; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; acetic acid 1.) from 100 deg C to 105 deg C, 2 h, 2.) reflux, 30 min; Yield given. Multistep reaction;
参考文献
Katritzky, A.R.; Rachwal, B.; Rachwal, S.; Smith, T.P.
Polish Journal of Chemistry, 1994 , vol. 68, # 11 p. 2153 - 2166
反应条件
thionyl chloride in dichloromethane 1 h; Reflux;
参考文献
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER; UNIVERSITY OF CINCINNATI; Merino, Edward J.; Mulloy, James C.; Li, Guorui; Bell-Horwath, Tiffany
Patent: US2013/230542 A1, 2013 ;
Location in patent: Paragraph 0123 ;
反应条件
1: 86 percent / Et3N / 2 h / Ambient temperature 2: 75 percent / NH3(g) / methanol / 1.) 0 deg C, 2 h 2.) rt, 2 h View Scheme
参考文献
Wimalasena, Kandatege; May, Sheldon W.
Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 4036 - 4046
反应条件
ion-exchange resin lt;H+ formgt;
参考文献
Gauvreau,A.; Lattes,A.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1162 - 1164
反应条件
1: thionyl chloride
View Scheme
参考文献
I.G.Farbenind.
Patent: DE488945 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2697
反应条件
1: N-methyl-N-phenyl-N-(2-hydroxyethyl)amine With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=0 - 20°C; Inert atmosphere;
参考文献
Tayama, Eiji; Ishikawa, Moe; Iwamoto, Hajime; Hasegawa, Eietsu
Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5159 - 5161
反应条件
1: N-methyl-N-phenyl-N-(2-hydroxyethyl)amine With sodium hydride in tetrahydrofuran
T=20°C; deprotonation; 1 h;
2: dimethyl sulfate in tetrahydrofuran
T=20°C; Methylation;
参考文献
Kostas, Ioannis D.; Screttas, Constantinos G.
Journal of Organometallic Chemistry, 1999 , vol. 585, # 1 p. 1 - 6
反应条件
acetic acid in water
4 h;
参考文献
Freiberg, Stephan; Lagugne-Labarthet, Francois; Rochon, Paul; Natansohn, Almeria
Macromolecules, 2003 , vol. 36, # 8 p. 2680 - 2688
反应条件
1: POCl3
2: (nitrosation)
3: SnCl2, aq. HCl
View Scheme
参考文献
Bardos; Datta-Gupta; Hebborn
Journal of medicinal chemistry, 1966 , vol. 9, # 2 p. 221 - 227
反应条件
phosphorus tribromide in dichloromethane
3 h; Ambient temperature;
参考文献
Thomas; Biju; George; Guldi; Kamat
Journal of Physical Chemistry A, 1998 , vol. 102, # 28 p. 5341 - 5348
