in tetrahydrofuran; water T=20°C;

1: 7-Benzyl-2,7-diaza-spiro[3.5]nonan-1-one With lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereReflux; 2: di-tert-butyl dicarbonate in dichloromethane 60 h;

1.1: hydrogen / methanol / 50 °C / 2068.65 Torr 2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 2.2: 60 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 5 °C / Inert atmosphere 2.2: 1 h / 5 °C 3.1: hydrogen / methanol / 50 °C / 2068.65 Torr 4.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 4.2: 60 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 5 °C / Inert atmosphere 2.2: 1 h / 5 °C 3.1: hydrogen / methanol / 50 °C / 2068.65 Torr 4.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 4.2: 60 h View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 5 °C / Inert atmosphere 1.2: 1 h / 5 °C 2.1: hydrogen / methanol / 50 °C / 2068.65 Torr 3.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 3.2: 60 h View Scheme

1: With hydrogen; palladium dihydroxide in methanol T=35°C; P=2844.39 Torr; 2: With hydrogenchloride in methanol; diethyl ether pH=6 - 7;