4-氨基-2,6-二氯烟酸合成路线 （共 9 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 12 h;
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1: n-BuLi / diethyl ether / -78 - 20 °C
2: TFA / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1: NaHDMS / tetrahydrofuran / 3 h / 29 °C
2: n-BuLi / diethyl ether / -78 - 20 °C
3: TFA / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1: With thionyl chloride in 1,2-dichloro-ethane
3 h; Heating;
2: With ammonium hydroxide in diethyl ether
T=0°C; 0.333333 h;
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C
2.1: 38 percent / 12 h / Heating
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C
2.1: 38 percent / 12 h / Heating
3.1: NEt3 / dioxane / 24 h / 80 °C
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C
2.1: 38 percent / 12 h / Heating
3.1: Pd(PPh3)4 / dioxane / 1 h / Heating
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C
2.1: 3 h / Heating
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C
2.1: 3 h / Heating
3.1: NEt3 / dioxane / 24 h / 80 °C
View Scheme
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Gao, Ling-Jie; Herdewijn, Piet
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8917 - 8920
