lithium chloride; copper dichloride in tetrahydrofuran T=0°C; 2.5 h;

magnesium; ethylene dibromide in tetrahydrofuran T=-20°C;

pyridine; thionyl chloride; chloroform

暂无反应条件数据

1: potassium iodide; potassium carbonate; caesium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / |Large scale 2: potassium hydroxide / water; ethanol / 16 h / 20 - 60 °C / |Large scale 3: sodium hydroxide; CoCl2.6H2O; Acylase I / water / 7 h / 20 - 38.5 °C / pH 7.5 - 7.8 View Scheme

(i) Mg, Et2O, (ii) /BRN= 1900390/; Multistep reaction;