反应条件
1: Br2 / CH2Cl2 / 2 h / Ambient temperature 2: KOH / ethanol / 16 h / Heating 3: Et3N / CH2Cl2 / 24 h / Ambient temperature 4: NH3 / ethanol / 2 h 5: 50 percent / Et3N / CH2Cl2 / 24 h / Ambient temperature 6: 1.) O3, 2.) Me2S / 1) CH2Cl2, MeOH, -78 deg C; 2) CH2Cl2, MeOH, 4 h 7: 80 percent / immobilized penicillin acylase / ethanol / 0.5 h / 23 °C / pH 7.5 View Scheme
参考文献
Favino, Tito Fabrizio; Fronza, Giovanni; Fuganti, Claudio; Fuganti, Daniela; Grasselli, Piero; Mele, Andrea
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 8975 - 8979