2,3,4,5-四氢-7-甲氧基-4-甲基-1,4-苯并硫氮杂卓合成路线 （共 4 条）
反应条件
hydrogenchloride; sodium cyanoborohydride in methanol
T=20°C; pH=4 - 5; 0.5 h;
参考文献
Smith, Chris D.; Wang, Aixia; Vembaiyan, Kannan; Zhang, Jingqun; Xie, Cuihong; Zhou, Qiang; Wu, Guogen; Chen, S. R. Wayne; Back, Thomas G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8626 - 8655
反应条件
1: trifluoroacetic acid; trimethylsilylazide / 48 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / |Reflux
3: sodium cyanoborohydride; hydrogenchloride / methanol / 0.5 h / 20 °C / pH 4 - 5
View Scheme
参考文献
Smith, Chris D.; Wang, Aixia; Vembaiyan, Kannan; Zhang, Jingqun; Xie, Cuihong; Zhou, Qiang; Wu, Guogen; Chen, S. R. Wayne; Back, Thomas G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8626 - 8655
反应条件
1: borax / water / 20 °C
2: sodium hydroxide / methanol / 20 °C
3: trifluoroacetic acid; trifluoroacetic anhydride / 60 °C
4: trifluoroacetic acid; trimethylsilylazide / 48 h / 20 °C
5: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / |Reflux
6: sodium cyanoborohydride; hydrogenchloride / methanol / 0.5 h / 20 °C / pH 4 - 5
View Scheme
参考文献
Smith, Chris D.; Wang, Aixia; Vembaiyan, Kannan; Zhang, Jingqun; Xie, Cuihong; Zhou, Qiang; Wu, Guogen; Chen, S. R. Wayne; Back, Thomas G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8626 - 8655
反应条件
1: trifluoroacetic acid; trifluoroacetic anhydride / 60 °C
2: trifluoroacetic acid; trimethylsilylazide / 48 h / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / |Reflux
4: sodium cyanoborohydride; hydrogenchloride / methanol / 0.5 h / 20 °C / pH 4 - 5
View Scheme
参考文献
Smith, Chris D.; Wang, Aixia; Vembaiyan, Kannan; Zhang, Jingqun; Xie, Cuihong; Zhou, Qiang; Wu, Guogen; Chen, S. R. Wayne; Back, Thomas G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8626 - 8655
