1: 92 percent / H2, triethylamine / 10percent palladised charcoal / tetrahydrofuran / 760 Torr / Ambient temperature 2: 85 percent / 1) toluene p-sulfonic acid hydrate; 2) HBr / CH2Cl2; methanol / 16 h 3: 42 percent / trifluoroacetic acid / 0.25 h / Ambient temperature 4: 54 percent / 3percent aqeous sodium hydroxide / pyridine / 2.5 h / Heating View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / lead tetra-acetate / acetic acid / Ambient temperature<br />2: 81 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 &deg;C<br /> <br /> &nbsp;