(E)-3-氧代丁-1-烯-1-酸钠合成路线 （共 5 条）
反应条件
sodium methylate
T=20°C; 0.666667 h;
参考文献
KALYPSYS, INC.
Patent: US2007/27184 A1, 2007 ;
Location in patent: Page/Page column 25 ;
US 20070027184 A1
反应条件
NaOEt in tert-butyl methyl ether
T=50°C; P=15201 Torr; AutoclaveInert atmosphere;
参考文献
Desrosiers, Jean-Nicolas; Kelly, Christopher B.; Fandrick, Daniel R.; Nummy, Larry; Campbell, Scot J.; Wei, Xudong; Sarvestani, Max; Lee, Heewon; Sienkiewicz, Alexander; Sanyal, Sanjit; Zeng, Xingzhong; Grinberg, Nelu; Ma, Shengli; Song, Jinhua J.; Senanayake, Chris H.
Organic Letters, 2014 , vol. 16, # 6 p. 1724 - 1727
反应条件
in diethyl ether; acetone
0.5 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2005/68444 A2, 2005 ;
Location in patent: Page/Page column 79 ;
反应条件
sodium methylate in diethyl ether
T=25 - 30°C; 0.25 h;
参考文献
Lipinski, Christopher A.; Blizniak, Thaddeus E.; Craig, Rebecca H.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 566 - 570
反应条件
n-butyllithium; diisopropylamine
1) THF, -5 deg C, 15 min, 2) -5 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Crimmins, Michael T.; O'Mahony, Rosemary
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900
