4-氯-1-[三(1-甲基乙基)硅酯]-1H-吡咯并[2,3-B]吡啶-5-甲醛合成路线 （共 3 条）
反应条件
1: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine With sec.-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.75 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78°C; 1 h;
3: With hydrogenchloride; sodium hydrogencarbonate
more than 3 stages;
参考文献
IRM LLC; THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2007/22268 A2, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/022268 A2
反应条件
1: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine With sec.-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.75 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
IRM LLC
Patent: US2010/48552 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine With sec.-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.75 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78°C; 1 h;
3: With hydrogenchloride; sodium hydrogencarbonate
more than 3 stages;
参考文献
IRM LLC
Patent: WO2006/124731 A2, 2006 ;
Location in patent: Page/Page column 25-26 ;
WO 2006/124731 A2
