1: 1.) DMSO, C2O2Cl2; 2.) N(C2H5)3 / 1.) CH2Cl2, -60 deg C, 15 min; 2.) -60 to 25 deg C 2: 80 percent / NaCH3COO / methanol / 1 h / Heating 3: 71 percent / NaBH3CN, 1 N HCl / methanol / 20 h / -40 °C 4: 2.) 10percent NH3 / 1.) CH3OH, 0 deg C, 3 h; 2.) CH3OH, 0.5 h 5: 84 percent / <(C6H5)3P>3RhCl / acetonitrile; H2O / 3 h / Heating 6: 76 percent / trifluoro acetic acid / 8 h / 0 °C 7: 46 percent / H2 / 10percent Pd/C / ethanol / 4 h 8: 1.) 6 N HCl; 2.) H2 / 2.) 10percent Pd/C / 1.) reflux, 2 h; 2.) H2O, 25 deg C, 7 h View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 55 percent / conc. H₂SO₄ / dioxane / 72 h / 20 &deg;C<br />2: 80 percent / tetrabutylammoniumiodide; NEt₃ / tetrahydrofuran / 48 h / Heating<br />3: 71 percent / LiBH₄ / tetrahydrofuran / 36 h / 20 &deg;C<br /> <br /> &nbsp;