5-(4-氯苯基)-3-甲酰基噻吩-2-羧酸合成路线 （共 3 条）
反应条件
1: 5-(4-chloro-phenyl)-thiophene-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 4 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-70 - -10°C; 2 h;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
T=-30 - 20°C;
参考文献
ASTRAZENECA AB
Patent: US2008/51405 A1, 2008 ;
Location in patent: Page/Page column 13 ;
US 20080051405 A1
反应条件
1: 5-(4-chloro-phenyl)-thiophene-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 4 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-70 - -10°C; 2 h;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
T=-30 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/11284 A1, 2007 ;
Location in patent: Page/Page column 31-32 ;
WO 2007/011284 A1
反应条件
hydrogenchloride; hydrazine in ethanol; water
T=82°C; 48 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/11284 A1, 2007 ;
Location in patent: Page/Page column 32 ;
WO 2007/011284 A1
