6-溴-3-苯基-4(3h)-喹唑啉酮合成路线 （共 7 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; HATU in acetonitrile
T=20°C; 25 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen; MATHIEU, Simon; MORENO, David; REN, Li; RUDOLPH, Joachim; WENGLOWSKY, Steven Mark
Patent: WO2012/118492 A1, 2012 ;
Location in patent: Page/Page column 80 ;
WO 2012/118492 A1
反应条件
N-bromosuccinmide in chloroform
T=50°C;
参考文献
Cabrera-Rivera, Fanny A.; Ortiz-Nava, Claudia; Roman-Bravo, Perla; Escalante, Jaime; Leyva, Marco A.
Heterocycles, 2012 , vol. 85, # 9 p. 2173 - 2195,23
反应条件
di-tert-butyl peroxide; toluene-4-sulfonic acid
T=110°C; 20 h; Schlenk technique;
参考文献
Zhao, Dan; Wang, Teng; Li, Jian-Xin
Chemical Communications, 2014 , vol. 50, # 49 p. 6471 - 6474
反应条件
1: ethyl acetate / 4 h / 90 °C / |Microwave irradiation
2: toluene-4-sulfonic acid / dichloromethane / 6 h / |Reflux; |Darkness
3: N-bromosuccinmide / chloroform / 50 °C
View Scheme
参考文献
Cabrera-Rivera, Fanny A.; Ortiz-Nava, Claudia; Roman-Bravo, Perla; Escalante, Jaime; Leyva, Marco A.
Heterocycles, 2012 , vol. 85, # 9 p. 2173 - 2195,23
反应条件
1: ethyl acetate / 4 h / 90 °C / |Microwave irradiation
2: toluene-4-sulfonic acid / dichloromethane / 6 h / |Reflux; |Darkness
3: N-bromosuccinmide / chloroform / 50 °C
View Scheme
参考文献
Cabrera-Rivera, Fanny A.; Ortiz-Nava, Claudia; Roman-Bravo, Perla; Escalante, Jaime; Leyva, Marco A.
Heterocycles, 2012 , vol. 85, # 9 p. 2173 - 2195,23
反应条件
1: toluene-4-sulfonic acid / dichloromethane / 6 h / |Reflux; |Darkness
2: N-bromosuccinmide / chloroform / 50 °C
View Scheme
参考文献
Cabrera-Rivera, Fanny A.; Ortiz-Nava, Claudia; Roman-Bravo, Perla; Escalante, Jaime; Leyva, Marco A.
Heterocycles, 2012 , vol. 85, # 9 p. 2173 - 2195,23
反应条件
1: iodine / ethanol / |Reflux
2: toluene-4-sulfonic acid; di-tert-butyl peroxide / 20 h / 110 °C / |Schlenk technique
View Scheme
参考文献
Zhao, Dan; Wang, Teng; Li, Jian-Xin
Chemical Communications, 2014 , vol. 50, # 49 p. 6471 - 6474
