3-甲基-5-苯基-4-异噁唑羧酸乙酯合成路线 （共 8 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water T=20°C; 2: With hydrogenchloride in water pH=4;
参考文献
Cheng, Huimin; Wan, Junting; Lin, Meng-I; Liu, Yingxue; Lu, Xiaoyun; Liu, Jinsong; Xu, Yong; Chen, Jianxin; Tu, Zhengchao; Cheng, Yih-Shyun E.; Ding, Ke
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2144 - 2153
反应条件
hydroxylamine hydrochloride in ethanol; water
T=60°C;
参考文献
Cheng, Huimin; Wan, Junting; Lin, Meng-I; Liu, Yingxue; Lu, Xiaoyun; Liu, Jinsong; Xu, Yong; Chen, Jianxin; Tu, Zhengchao; Cheng, Yih-Shyun E.; Ding, Ke
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2144 - 2153
反应条件
1: diethyl ether; pyridine
2: alcohol; hydroxylamine hydrochloride
View Scheme
参考文献
Benary
Chemische Berichte, 1909 , vol. 42, p. 3919
反应条件
1.1: sodium hydroxide / Petroleum ether / 0.5 h / 0 °C
1.2: 2 h / 0 - 35 °C
2.1: hydroxylamine hydrochloride / ethanol; water / 60 °C
View Scheme
参考文献
Cheng, Huimin; Wan, Junting; Lin, Meng-I; Liu, Yingxue; Lu, Xiaoyun; Liu, Jinsong; Xu, Yong; Chen, Jianxin; Tu, Zhengchao; Cheng, Yih-Shyun E.; Ding, Ke
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2144 - 2153
反应条件
hydroxylamine hydrochloride; sodium acetate; acetic acid
参考文献
Betti; Alessandri
Gazzetta Chimica Italiana, 1915 , vol. 45 I, p. 466
Full Text Show Details
Betti; Pacini
Gazzetta Chimica Italiana, 1915 , vol. 45 II, p. 381
反应条件
ethanol; hydroxylamine hydrochloride
参考文献
Benary
Chemische Berichte, 1909 , vol. 42, p. 3919
反应条件
pyridine; hydroxylamine hydrochloride
1.) Et2O, RT, 48 h, 2.) AcOH, reflux, 0.5 h; Yield given. Multistep reaction;
参考文献
Chen, Ya Ping; Chantegrel, Bernard; Deshayes, Christian
Heterocycles, 1995 , vol. 41, # 1 p. 175 - 186
反应条件
1: diethyl ether; pyridine
2: alcohol; hydroxylamine hydrochloride
View Scheme
参考文献
Benary
Chemische Berichte, 1909 , vol. 42, p. 3919
