4-(2-溴苯基)丁酰氯合成路线 （共 17 条）
反应条件
aluminium trichloride in carbon disulfide 3 h; Heating;
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 96 percent / tetrahydrofuran; diethyl ether / 1.5 h / Heating
2: 73 percent / 9-BBN, 6M NaOH, 30percent H2O2 / 1.5 h / 50 °C
3: 66 percent / chromium trioxide, 1.5M sulfuric acid / acetone / 4 h / 0 °C
4: thionyl chloride / 2.5 h / Ambient temperature
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 58 percent / chromium trioxide; acetic acid / 18 h / 20 °C
2: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Ghoneim, Ola M.; Legere, Jacqueline A.; Golbraikh, Alexander; Tropsha, Alexander; Booth, Raymond G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6640 - 6658
反应条件
1.1: 9-borabicyclo[3.3.1]nonane / hexane / 18 h / 20 °C
1.2: 82 percent / NaOH; H2O2 / tetrahydrofuran / 1.5 h / 50 °C
2.1: 58 percent / chromium trioxide; acetic acid / 18 h / 20 °C
3.1: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Ghoneim, Ola M.; Legere, Jacqueline A.; Golbraikh, Alexander; Tropsha, Alexander; Booth, Raymond G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6640 - 6658
反应条件
1: 63 percent / NaOEt / 7 h / Heating
2: 98 percent / KOH / ethanol; H2O / 6 h / Heating
3: 95 percent / 170 °C
4: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 91 percent / sulfuric acid / H2O / 4 h / Heating
2: 84 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 72 percent / 48percent HBr, H2SO4 / 3 h / Heating
4: 63 percent / NaOEt / 7 h / Heating
5: 98 percent / KOH / ethanol; H2O / 6 h / Heating
6: 95 percent / 170 °C
7: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 84 percent / LiAlH4 / diethyl ether / 1 h / Heating
2: 72 percent / 48percent HBr, H2SO4 / 3 h / Heating
3: 63 percent / NaOEt / 7 h / Heating
4: 98 percent / KOH / ethanol; H2O / 6 h / Heating
5: 95 percent / 170 °C
6: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 72 percent / 48percent HBr, H2SO4 / 3 h / Heating
2: 63 percent / NaOEt / 7 h / Heating
3: 98 percent / KOH / ethanol; H2O / 6 h / Heating
4: 95 percent / 170 °C
5: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 98 percent / KOH / ethanol; H2O / 6 h / Heating
2: 95 percent / 170 °C
3: thionyl chloride / 0.75 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
thionyl chloride
0.75 h; Heating;
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
Title/Abstract Full Text View citing articles Show Details
Ghoneim, Ola M.; Legere, Jacqueline A.; Golbraikh, Alexander; Tropsha, Alexander; Booth, Raymond G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6640 - 6658
