3-(N,N-二羟乙基)氨基乙酰苯胺合成路线 （共 5 条）
反应条件
calcium carbonate; potassium iodide in water 8 h; Reflux;
参考文献
Lin, Song-Wen; Sun, Qi; Ge, Ze-Mei; Wang, Xin; Ye, Jia; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 940 - 943
反应条件
1: 1-amino-2-cyano-4-nitro-6-bromobenzene With nitrosyl-sulphuric acid; sulfuric acid T=5°C; 1 h; 2: N,N-bis(2-hydroxyethyl)-3-acetamidoaniline With aminosulfonic acid in water pH=2 - 3; 2 h; Cooling with ice;
参考文献
MERCK PATENT GMBH; FARRAND, Louise Diane; JAMES, Mark; MARKHAM, Emily Jane; TOPPING, Claire; WILSON, Jonathan Henry
Patent: WO2012/19704 A1, 2012 ;
Location in patent: Page/Page column 107 ;
反应条件
triethylamine in ethyl acetate T=20°C; 1 h;
参考文献
Lin, Song-Wen; Sun, Qi; Ge, Ze-Mei; Wang, Xin; Ye, Jia; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 940 - 943
反应条件
pyridine in acetic acid 0.5 h;
参考文献
Thiel, W.; Mayer, R.; Jauer, E.-A.; Modrow, H.; Dost, H.
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 497 - 514
反应条件
hydrogenchloride; water
1 h; Reflux;
参考文献
MERCK PATENT GMBH; FARRAND, Louise Diane; JAMES, Mark; MARKHAM, Emily Jane; TOPPING, Claire; WILSON, Jonathan Henry
Patent: WO2012/19704 A1, 2012 ;
Location in patent: Page/Page column 91 ;
