5-溴-2-羟基-3-硝基苯羧酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid; nitric acid in water T=0 - 5°C;
参考文献
LEAD THERAPEUTICS, INC.
Patent: US2009/197863 A1, 2009 ;
Location in patent: Page/Page column 56 ;
反应条件
sodium acetate in water; ethyl acetate T=25°C; P=760.051 Torr; 16 h;
参考文献
LEAD THERAPEUTICS, INC.
Patent: US2009/197863 A1, 2009 ;
Location in patent: Page/Page column 56 ;
反应条件
1: 91.3 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C 2: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C 3: K2CO3 / dimethylformamide / 2 h / 70 °C View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
反应条件
iron; ammonium chloride in toluene T=85 - 90°C; 1 h;
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
