反应条件
1: 3-hydroxy-5-methoxy-3-phenyl-3H-isobenzofuran-1-one With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C;
2: N-cyanomethyl-N-methylamine hydrochloride With triethylamine in dichloromethane
T=20°C;
参考文献
Trotter, B. Wesley; Nanda, Kausik K.; Kett, Nathan R.; Regan, Christopher P.; Lynch, Joseph J.; Stump, Gary L.; Kiss, Laszlo; Wang, Jixin; Spencer, Robert H.; Kane, Stefanie A.; White, Rebecca B.; Zhang, Rena; Anderson, Kenneth D.; Liverton, Nigel J.; McIntyre, Charles J.; Beshore, Douglas C.; Hartman, George D.; Dinsmore, Christopher J.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 6954 - 6957