1: acetonitrile With potassium tert-butylate; 18-crown-6 ether in tetrahydrofuran T=60°C; 0.0833333 h; 2: isonicotinic acid ethyl ester in tetrahydrofuran 0.5 h; 3: With hydrogenchloride; N-methoxycarbonyl hydrazine in ethanol; water T=30°C; 20 h; Cooling with ice;

hydrogenchloride; sodium sulfate

hydrazine in ethanol 18 h; Reflux;

1.1: n-butyllithium / hexane; toluene / 0.33 h / -78 °C / Inert atmosphere 1.2: 0.33 h / 20 °C / Inert atmosphere 2.1: hydrazine hydrate / ethanol / 18 h / Reflux View Scheme