triethylamine in 1,4-dioxane T=80°C; 24 h;

1.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating 1.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C 2.1: 38 percent / 12 h / Heating 3.1: NEt3 / dioxane / 24 h / 80 °C View Scheme

1: 38 percent / 12 h / Heating 2: NEt3 / dioxane / 24 h / 80 °C View Scheme

1.1: n-BuLi / diethyl ether / -78 - 20 °C 2.1: TFA / CH2Cl2 / 12 h / 20 °C 3.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating 3.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C 4.1: 38 percent / 12 h / Heating 5.1: NEt3 / dioxane / 24 h / 80 °C View Scheme

1.1: TFA / CH2Cl2 / 12 h / 20 °C 2.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating 2.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C 3.1: 38 percent / 12 h / Heating 4.1: NEt3 / dioxane / 24 h / 80 °C View Scheme

1.1: NaHDMS / tetrahydrofuran / 3 h / 29 °C 2.1: n-BuLi / diethyl ether / -78 - 20 °C 3.1: TFA / CH2Cl2 / 12 h / 20 °C 4.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating 4.2: aq. NH3 / diethyl ether / 0.33 h / 0 °C 5.1: 38 percent / 12 h / Heating 6.1: NEt3 / dioxane / 24 h / 80 °C View Scheme