4-羟基-α-(1-羟基环己基)苯乙腈合成路线 （共 5 条）
反应条件
1: With potassium tert-butylate T=20°C; 1.5 h; 2: With hydrogenchloride in water; ethyl acetate pH=3 - 4; Product distribution / selectivity;
参考文献
SIEGFRIED LTD.
Patent: WO2007/294 A1, 2007 ;
Location in patent: Page/Page column 6-7 ;
反应条件
hydrogen; palladium on activated charcoal in 1,4-dioxane T=50°C; P=3750.38 Torr; 10 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 20-21; 23 ;
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in methanol T=20°C; P=7355.72 - 8826.87 Torr; 10 - 12 h; Product distribution / selectivity;
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2009/84037 A2, 2009 ;
Location in patent: Page/Page column 5; 7; 9; 20-21 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=50°C; P=3750.38 Torr; 10 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 20-21; 24-25-26 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=50°C; P=3750.38 Torr; 10 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe
Patent: WO2009/144517 A1, 2009 ;
Location in patent: Page/Page column 20-21; 24-25-26 ;
