1: With methyllithium in tetrahydrofuran; diethyl ether
T=-55 - 20°C;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 191-192 ;
WO 2006/136830 A1