1: N,N-dimethylpyrazole-1-sulfonamide With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: ethyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; ASTRAZENECA AB
Patent: WO2006/136829 A2, 2006 ;
Location in patent: Page/Page column 129-130 ;
WO 2006/136829 A2
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 191 ;
WO 2006/136830 A1
