5-氟-6-羟基-1-茚满酮合成路线 （共 5 条）
反应条件
sodium chloride; AlCl3, aluminium chloride
T=185°C; 0.25 h;
参考文献
WYETH
Patent: WO2006/138549 A1, 2006 ;
Location in patent: Page/Page column 78-79 ;
WO 2006/138549 A1
反应条件
boron tribromide in dichloromethane
T=20°C; 7 h; Cooling with ice;
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1.1: triethylammonium formate / 5 h / 100 °C
1.2: 20 °C / pH 1
2.1: thionyl chloride / toluene / 1 h / 90 °C
2.2: 1 h / Cooling with ice
2.3: 1 h / Cooling with ice
3.1: boron tribromide / dichloromethane / 7 h / 20 °C / Cooling with ice
View Scheme
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
反应条件
1.1: thionyl chloride / toluene / 1 h / 90 °C
1.2: 1 h / Cooling with ice
1.3: 1 h / Cooling with ice
2.1: boron tribromide / dichloromethane / 7 h / 20 °C / Cooling with ice
View Scheme
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
反应条件
sodium azide; methanesulfonic acid in chloroform
Schmidt reaction;
参考文献
Shen, Zhongqi; Siva Ramamoorthy; Hatzenbuhler, Nicole T.; Evrard, Deborah A.; Childers, Wayne; Harrison, Boyd L.; Chlenov, Michael; Hornby, Geoffrey; Smith, Deborah L.; Sullivan, Kelly M.; Schechter, Lee E.; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 222 - 227
