(S)-(+)-1-苄基-3-羟基哌啶合成路线 （共 13 条）
反应条件
1: With trifluoroacetic anhydride in tetrahydrofuran T=-78°C; 1 h; 2: With triethylamine in tetrahydrofuran T=-78°C; 60.3333 h; Reflux; 3: With sodium hydroxide in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Kovackova, Sona; Dracinsky, Martin; Rejman, Dominik
Tetrahedron, 2011 , vol. 67, # 7 p. 1485 - 1500
反应条件
Daucus carota; water in ethanol T=20°C; 48 h; enantioselective reaction;
参考文献
Lacheretz, Romain; Pardo, Domingo Gomez; Cossy, Janine
Organic Letters, 2009 , vol. 11, # 6 p. 1245 - 1248
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Reflux;
参考文献
Lacheretz, Romain; Pardo, Domingo Gomez; Cossy, Janine
Organic Letters, 2009 , vol. 11, # 6 p. 1245 - 1248
反应条件
triethylamine in toluene 5 h; Heating;
参考文献
Muto; Kuroda; Kawato; Karasawa; Kubo; Nakamizo
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 11 A p. 1662 - 1665
反应条件
1.1: triethylamine / dichloromethane / 10 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h 2.2: 0 °C 3.1: trifluoroacetic anhydride / tetrahydrofuran / 1 h / -78 °C 3.2: 60.33 h / -78 °C / Reflux 3.3: 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
1.1: triethylamine / dichloromethane / 10 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h 2.2: 0 °C 3.1: trifluoroacetic anhydride / tetrahydrofuran / 1 h / -78 °C 3.2: 60.33 h / -78 °C / Reflux 3.3: 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
1.1: thionyl chloride / 0 °C 2.1: triethylamine / dichloromethane / 10 h / Reflux 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h 3.2: 0 °C 4.1: trifluoroacetic anhydride / tetrahydrofuran / 1 h / -78 °C 4.2: 60.33 h / -78 °C / Reflux 4.3: 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
IL1-PS lipase in toluene T=20°C; 20 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 13 p. 2321 - 2327
反应条件
2: 47 percent / triethylamine / toluene / 5 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 38, # 11 A p. 1662 - 1665
反应条件
Bacillus licheniformis subtilisin; water T=20°C; 16 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 18 p. 2112 - 2116
