1-(二氟甲基)-1H-咪唑合成路线 （共 5 条）
反应条件
water; zinc in methanol
T=20°C; 24 h;
参考文献
Bissky, German; Roeschenthaler, Gerd-Volker; Lork, Enno; Barten, Jan; Medebielle, Maurice; Staninets, Vasilij; Kolomeitsev, Alexander A.
Journal of Fluorine Chemistry, 2001 , vol. 109, # 2 p. 173 - 181
反应条件
dibenzo-18-crown-6; potassium hydroxide in ethylene glycol dimethyl ether; water
Heating;
参考文献
Levterov, Vadym; Grygorenko, Oleksandr O.; Mykhailiuk, Pavel K.; Tolmachev, Andrey A.
Synthesis, 2011 , # 8 art. no. N50310SS, p. 1243 - 1248
反应条件
1: 1H-imidazole With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h; Inert atmosphere;
2: PhSO(NTS)CF2D in N,N-dimethyl-formamide
T=20 - 60°C;
参考文献
Zhang, Wei; Wang, Fei; Hu, Jinbo
Organic Letters, 2009 , vol. 11, # 10 p. 2109 - 2112
反应条件
lithium iodide in triglyme (triethylene glycol dimethyl ether)
T=170°C; 1.5 h; Inert atmosphereMicrowave irradiation; Time;
参考文献
Surya Prakash; Krishnamoorthy, Sankarganesh; Ganesh, Somesh K.; Kulkarni, Aditya; Haiges, Ralf; Olah, George A.
Organic Letters, 2014 , vol. 16, # 1 p. 54 - 57
反应条件
in diethylene glycol dimethyl ether; water
T=160°C; 11 h;
参考文献
Poludnenko, V. G.; Didinskaya, O. B.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 4 p. 422 - 425
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 4 p. 520 - 523
