反应条件
1: 5-bromo-2-fluoro-4-methoxybenzaldehyde dimethylacetal in tetrahydrofuran
T=-70°C; 0.333333 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 0.166667 h;
3: N,N-dimethyl benzamide With water; toluene-4-sulfonic acid
more than 3 stages;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: WO2006/118256 A1, 2006 ;
Location in patent: Page/Page column 90 ;