2-甲基-2-丙基3-(2H-四唑-5-基)-1-哌啶羧酸酯合成路线 （共 4 条）
反应条件
sodium azide; ammonium chloride in N,N-dimethyl-formamide
T=100°C;
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
反应条件
sodium hydroxide; potassium carbonate in tetrahydrofuran
16 h; Yield given;
参考文献
Moltzen; Pedersen; Bogeso; Meier; Frederiksen; Sanchez; Lembol
Journal of Medicinal Chemistry, 1994 , vol. 37, # 24 p. 4085 - 4099
反应条件
1: POCl3 / pyridine
2: 50 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
反应条件
1: 1.) Et3N, ClCO2C2H5; 2.) NH3 / 1.) chloroform, 0 deg C, 8 min; 2.) chloroform, RT, 2-4 h
2: POCl3 / pyridine
3: 50 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
