7-羟基-4H-苯并[1,4]噻嗪-3-酮合成路线 （共 7 条）
反应条件
boron tribromide in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Zhang, Li-Qiu; Guan, Li-Ping; Wei, Cheng-Xi; Deng, Xian-Qing; Quan, Zhe-Shan
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 326 - 331
反应条件
acetic acid; urea in water
参考文献
Mediolanum Farmaceutici S.R.L.
Patent: US4535079 A1, 1985 ;
US 4535079 A
反应条件
1: 77 percent / aq. K2CO3 / tetrahydrofuran
2: 76 percent / BBr3*Me2S / toluene / Heating
View Scheme
参考文献
Jones; Venuti; Alvarez; Bruno; Berks; Prince
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303
反应条件
sulfuric acid; sodium nitrite in water; acetic acid
1 h; Ambient temperature;
参考文献
Cecchetti; Fravolini; Fringuelli; Schiaffella; Mascellani; Pagella; Rugarli
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 1 p. 61 - 75
反应条件
1: potassium hydroxide / water / 20 h / |Reflux
2: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 2.67 h / 0 °C / |Reflux
3: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
反应条件
sodium hydroxide; oxygen
0.166667 h;
参考文献
Crescenzi, Orlando; Prota, Giuseppe; Schultz, Thomas M.; Wolfram, Leszek J.
Gazzetta Chimica Italiana, 1990 , vol. 120, # 1 p. 21 - 24
反应条件
1: BPSS2111-2113:A With potassium carbonate in ethanol
0.5 h; Reflux;
2: ethyl bromide in ethanol
Reflux;
参考文献
Zhang, Li-Qiu; Guan, Li-Ping; Wei, Cheng-Xi; Deng, Xian-Qing; Quan, Zhe-Shan
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 326 - 331
