4-氯-3-甲基苯甲酸甲酯合成路线 (共 3 条)
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20 - 23°C;
参考文献
SANOFI-AVENTIS
Patent: WO2006/79857 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4416 - 4420
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane T=80°C; 4 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40568 A1, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/040568 A1