2-(4-溴苯基)-2,2-二氟乙酸合成路线 （共 4 条）
反应条件
silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water; acetone T=55°C; 1 h; Inert atmosphereSchlenk technique; Concentration;
参考文献
Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651
反应条件
potassium fluoride in 1-methyl-pyrrolidin-2-one T=200°C; 48 h; Inert atmosphere;
参考文献
Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki
Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563
反应条件
1: With methanol; sodium hydroxide; water in dichloromethane
2 h;
2: With hydrogenchloride in methanol; dichloromethane; water
参考文献
Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.
Patent: US2006/154973 A1, 2006 ;
Location in patent: Page/Page column 47 ;
反应条件
1: copper(l) iodide; potassium fluoride / dimethyl sulfoxide / 15 h / 60 °C / Inert atmosphere
2: water; potassium carbonate / methanol / 2 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki
Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563
