1,1-双(4-羟基苯基)-2-苯基丁-1-烯合成路线 （共 16 条）
反应条件
1: 4-(1-(4-hydroxylphenyl)-2-phenylbut-1-enyl)phenol With caesium carbonate in N,N-dimethyl-formamide T=70 - 80°C; 0.166667 h; 2: 2-dimethylamino-1-chloro-ethane hydrochloride in N,N-dimethyl-formamide T=70 - 80°C; 1.5 h;
参考文献
Yu, Donna D.; Forman, Barry M.
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9489 - 9491
反应条件
1: 4-(1-(4-hydroxylphenyl)-2-phenylbut-1-enyl)phenol With caesium carbonate in N,N-dimethyl-formamide 0.5 h; Reflux; 2: 2-dimethylamino-1-chloro-ethane hydrochloride in N,N-dimethyl-formamide T=120°C; 7 h;
参考文献
Ding, Song; Qiao, Xin; Kucera, Gregory L.; Bierbach, Ulrich
Chemical Communications, 2013 , vol. 49, # 24 p. 2415 - 2417
反应条件
1: 4-(1-(4-hydroxylphenyl)-2-phenylbut-1-enyl)phenol With caesium carbonate in N,N-dimethyl-formamide T=70 - 80°C; 0.166667 h; 2: 2-dimethylamino-1-chloro-ethane hydrochloride in N,N-dimethyl-formamide T=70 - 80°C; 1.5 h;
参考文献
Yu, Donna D.; Forman, Barry M.
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9489 - 9491
反应条件
titanium tetrachloride; zinc in tetrahydrofuran
T=0°C; McMurry reaction; 2 h; Inert atmosphereRefluxDarkness;
参考文献
Jiang, Quan; Zhong, Qiu; Zhang, Qiang; Zheng, Shilong; Wang, Guangdi
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 5 p. 392 - 396
反应条件
boron tribromide in dichloromethane
T=20°C; 72 h;
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
boron tribromide in dichloromethane
T=0°C; 2 h;
参考文献
Shiina, Isamu; Sano, Yoshiyuki; Nakata, Kenya; Kikuchi, Takaaki; Sasaki, Akane; Ikekita, Masahiko; Hasome, Yoshimune
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2421 - 2424
反应条件
sodium hydroxide in methanol
0.5 h; Ambient temperature;
参考文献
Ball; Schneider; Schonenberger
Archiv der Pharmazie, 1984 , vol. 317, # 6 p. 565 - 571
反应条件
1: potassium tert-butylate / diethyl ether / Heating
2: tetrahydrofuran / Heating
3: 47percent HBr / tetrahydrofuran
4: 62.4 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: tetrahydrofuran / Heating
2: 47percent HBr / tetrahydrofuran
3: 62.4 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: 76.8 percent / aluminium chloride / 1,2-dichloro-ethane / 2 h / Heating
2: potassium tert-butylate / diethyl ether / Heating
3: tetrahydrofuran / Heating
4: 47percent HBr / tetrahydrofuran
5: 62.4 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
