3-(4-氯苯基)-5-甲基-4-异?唑羧酸合成路线 （共 6 条）
反应条件
potassium hydroxide in ethanol; water 10 h; Heating;
参考文献
Akiba, Kin-ya; Kashiwagi, Kohichi; Ohyama, Yoshihiko; Yamamoto, Yoshuke; Ohkata, Katsuo
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2721 - 2730
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: 1.) N-bromosuccinimide / 1.) DMF, 10-15 degC, 2 h; 2.) 4 h, 0 degC, 15 h, room t. 2: 75 percent / potassium hydroxide / ethanol; H2O / 10 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, # 9 p. 2721 - 2730
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1201 - 1204
反应条件
sodium tetrahydroborate; chloroformic acid ethyl ester; triethylamine 1. THF, -10 deg C, 30 min 2. a. H2O, 5-10 deg C b. 3h, room temperature; Yield given. Multistep reaction;
参考文献
Heck, Reinhard; Ofenloch, Roland; Wolf, Roland
Synthesis, 1990 , # 1 p. 62 - 64
反应条件
sodium hydroxide; hydrogen; Raney Nickel (W2) in water
Ambient temperature;
参考文献
Akiba, Kin-ya; Kashiwagi, Kohichi; Ohyama, Yoshihiko; Yamamoto, Yoshuke; Ohkata, Katsuo
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2721 - 2730
