7-酮基-3alpha,12alpha-二羟基胆烷酸合成路线 （共 4 条）
→
2955-27-34-[(5S,7S,8S,10S,13R,17R)-3,7,12-三羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酸
反应条件
sodium in propan-1-ol 3 h; Reflux;
参考文献
Steroids, , vol. 76, # 12 p. 1397 - 1399
反应条件
cultures of aspergillus cinnamomeus
参考文献
Ando
Hiroshima med. J.Chem.Abstr., 1959 , vol. 7, p. 2589,2591
Hiroshima med. J.Chem.Abstr., 1960 , p. 22829
反应条件
1: sodium / propan-1-ol / 3 h / Reflux 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tert-butyl alcohol / 1 h / Reflux 3: hydrazine hydrate; potassium hydroxide; 1,2-bis-(2-hydroxyethoxy)-ethane / 110 - 135 °C View Scheme
参考文献
Dangate, Prasad S.; Salunke, Chetan L.; Akamanchi, Krishnacharya G.
Steroids, 2011 , vol. 76, # 12 p. 1397 - 1399
反应条件
1: hydrogenchloride / Reflux 2: pyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 12 h / 20 °C 3: bromine; acetic acid / 48 h / 20 °C 4: potassium hydroxide / methanol / 20 °C 5: toluene-4-sulfonic acid / 20 °C 6: zinc(II) chloride; sodium tetrahydroborate / diethyl ether View Scheme
参考文献
BRITISH COLUMBIA CANCER AGENCY BRANCH; LING, Victor; WANG, Renxue; SHEPS, Jonathan Ahab
Patent: WO2011/22838 A1, 2011 ;
