N-[4-(4-氟苯基)-5-[(1E)-3-羟基-1-丙烯-1-基]-6-(1-甲基乙基)-2-嘧啶基]-N-甲基-甲烷磺酰胺合成路线 （共 12 条）
反应条件
1: Oxonereg;; sodium hydrogencarbonate / tetrabutyl-ammonium chloride / dichloromethane; water; acetone / 16 h / 0 - 20 °C
2: 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 24 h / 40 °C
View Scheme
参考文献
LEK PHARMACEUTICALS D.D.; CASAR, Zdenko; STERK, Damjan; JUKIC, Marko
Patent: WO2012/13325 A1, 2012 ;
反应条件
dipyridinium dichromate in dichloromethane
T=20°C; 5.25 h; Molecular sieve;
参考文献
Dandala, Ramesh; Mallela, Sambhu Prasad Sarma; Garimella, Narayan K.A.S.S.; Nandi, Sukumar; Buridipad, Sunil Kumar; Nangi, Gangadhar Bhima Shankar; Meenakshisunderam, Sivakumaran
Patent: US2010/48899 A1, 2010 ;
Location in patent: Page/Page column 11 ;
