4-去甲氧基-10,10-二甲基柔红霉素合成路线 （共 6 条）
反应条件
sodium hydroxide in tetrahydrofuran
T=0°C; 16 h;
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
反应条件
1: 91 percent / diethyl ether / 10 h / 0 - 20 °C
2: 100 percent / bromotrimethylsilane / CHCl3 / 2 h / Ambient temperature
3: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h
4: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C
View Scheme
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
反应条件
1: 100 percent / bromotrimethylsilane / CHCl3 / 2 h / Ambient temperature
2: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h
3: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C
View Scheme
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
反应条件
1: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h
2: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C
View Scheme
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
反应条件
1: 9 percent / N-bromosuccinimide / CCl4 / 52 - 55 °C / Irradiation
2: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h
3: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C
View Scheme
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
反应条件
1: 13 percent / silver triflate / CH2Cl2; diethyl ether / 0.5 h
2: 0.1 N aq. NaOH / tetrahydrofuran / 16 h / 0 °C
View Scheme
参考文献
Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347
