1: 1) lithium diisopropylamide 2) bromine / 1) THF, 1h, -78 deg C 2) 20 min, -78 deg C 2: 94.3 percent / dimethylformamide / 2 h / Heating 3: 41 percent / 1.0M NaOH / methanol / 3 h / Heating View Scheme