5-甲氧基-1H-吲唑-3-羧酸甲酯合成路线 （共 4 条）
反应条件
1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 5.5 h / -10 - 20 °C 2: manganese(IV) oxide / ethyl acetate / 20 °C View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
反应条件
palladium diacetate; triethylamine; di-(1-adamantyl)-n-butylphosphine in toluene
T=70°C; P=750.075 Torr; Autoclave;
参考文献
Buchstaller, Hans-Peter; Wilkinson, Kai; Burek, Kasimir; Nisar, Yasmin
Synthesis, 2011 , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
sulfuric acid
T=20°C; 4 h;
参考文献
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
Patent: WO2008/61688 A1, 2008 ;
Location in patent: Page/Page column 26 ;
WO 2008/061688 A1
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C
1.2: 1 h / |Cooling with ice
1.3: 20 °C / |Cooling with ice
2.1: sulfuric acid / 3 h / |Reflux
View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
