1: hydrogenchloride; water / ethyl acetate 2: triethylamine / ethyl acetate; toluene 3: dirhodium(II) tetraoctanoate / acetone / Reflux 4: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 6: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme

1: hydrogenchloride; water / ethyl acetate 2: triethylamine / ethyl acetate; toluene 3: dirhodium(II) tetraoctanoate / acetone / Reflux 4: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C View Scheme

1: hydrogenchloride; water / ethyl acetate 2: triethylamine / ethyl acetate; toluene 3: dirhodium(II) tetraoctanoate / acetone / Reflux 4: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C View Scheme