toluene-4-sulfonic acid in methanol T=50°C; 12 h;

1: With methyllithium in tetrahydrofuran; diethyl ether T=-78°C; 0.25 h; 2: With toluene-4-sulfonic acid in acetone 4 h;

<b>Multi-step reaction with 2 steps<br /> </b>1: acetic acid; aluminum (III) chloride; bromine / 4 h / |Cooling with ice<br />2: potassium carbonate / acetone / 2 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: iodine; silver trifluoroacetate / chloroform / 27 h / 20 &deg;C<br />2: potassium carbonate / acetone / 2 h / 20 &deg;C<br /> <br /> &nbsp;