(4S)-N-巴豆酰基-4-异丙基-2-恶唑烷酮合成路线 （共 10 条）
反应条件
n-butyllithium in tetrahydrofuran 1.) -78 deg C;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.5 h; 2: crotonic acid chloride in tetrahydrofuran; hexanes T=-78°C; 0.5 h;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2003/106437 A1, 2003 ;
Location in patent: Page 51-52 ;
反应条件
triethylamine; lithium chloride in tetrahydrofuran T=-15 - 20°C; 12 h;
参考文献
Sakaguchi, Hiroshi; Tokuyama, Hidetoshi; Fukuyama, Tohru
Organic Letters, 2007 , vol. 9, # 9 p. 1635 - 1638
反应条件
in hexane; toluene 1.) -40 deg C, irradiation, 5 h; 2.) -20 deg C, 29 h, in the dark;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=760.051 Torr; 1 h;
参考文献
WO2003/106437 A1, ;
Page 52-53 ;
反应条件
1: (4S)-N-[(2E)-but-2-enoyl]-4-phenylmethyl-1,3-oxazolidin-2-one With anhydrous magnesium perchlorate in dichloromethane T=20°C; 2: perfluoromethyl iodide With triethyl borane; oxygen; tri-n-butyl-tin hydride in hexane; dichloromethane T=-40°C; Schlenk technique;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 43 p. 8583 - 8586
反应条件
in hexane; toluene 1.) -40 deg C, irradiation, 5 h; 2.) -20 deg C, 29 h, in the dark;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
1: in tetrahydrofuran
T=-78°C; Michael addition;
2: With water; ammonium chloride in tetrahydrofuran
optical yield given as percent destereoselective reaction;
参考文献
Zhou; Lu; Chen; Yang
Chemistry of Natural Compounds, 2010 , vol. 46, # 1 p. 83 - 85
反应条件
copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate in tetrahydrofuran
T=-78°C; 3 h; Yield given;
参考文献
Williams, David R.; Kissel, William S.; Li, Jie Jack
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8593 - 8596
反应条件
in hexane; toluene
T=-78°C; 0.8 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
