1-二苯甲基-3-羟基氮杂环丁烷盐酸盐合成路线 （共 13 条）
反应条件
hydrogenchloride in ethyl acetate T=20°C; 0.166667 h;
参考文献
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
Patent: WO2007/118830 A1, 2007 ;
Location in patent: Page/Page column 91 ;
WO 2007/118830 A1
参考文献
Terranova, Eric; Fadli, Aziz
Patent: US2003/28976 A1, 2003 ;
反应条件
sodium hydroxide; triethylamine in dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene
反应条件
1: aminodiphenylmethane hydrochloride With sodium hydroxide in dichloromethane; water T=20°C; Dehydrochlorination; 12 h; 2: epichlorohydrin in methanol T=20°C; Addition; cyclization; 72 h;
参考文献
Vuilhorgne, Marc; Commercon, Alain; Mignani, Serge
Chemistry Letters, 1999 , # 7 p. 605 - 606
反应条件
in dimethyl sulfoxide T=50°C;
参考文献
Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu
Journal of Antibiotics, 2006 , vol. 59, # 4 p. 241 - 247
反应条件
1: methanol / 24 h / 20 °C 2: 48 percent / dimethylsulfoxide / 50 °C View Scheme
参考文献
Journal of Antibiotics, , vol. 59, # 4 p. 241 - 247
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide T=0 - 20°C;
参考文献
Pfizer Inc.
Patent: US2010/190771 A1, 2010 ;
Location in patent: Page/Page column 38 ;
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6291457 B1, 2001 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; Product distribution / selectivity;
参考文献
Pfizer Inc.
Patent: US2010/190771 A1, 2010 ;
Location in patent: Page/Page column 28-29 ;
反应条件
1: 1-diphenylmethyl-3-hydroxy-azetidine hydrochloride With sodium carbonate in dichloromethane; water T=20°C; 2: di-tert-butyl dicarbonate With palladium on carbon; hydrogen in tetrahydrofuran T=20°C; P=1551.49 Torr; 18 h;
参考文献
INCYTE CORPORATION; ZHOU, Jiacheng; LIU, Pingli; CAO, Ganfeng; WU, Yongzhong
Patent: WO2013/36611 A1, 2013 ;
Location in patent: Page/Page column 27 ;
