N-Boc-L-烯丙基甘氨酸合成路线 （共 49 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 18 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/80983 A1, 2004 ;
Location in patent: Page 42-44 ;
WO 2004/080983 A1
反应条件
ammonia; lithium in tetrahydrofuran; ethanol T=-33°C; 0.25 h;
参考文献
Williams, Robert M.; Sinclair, Peter J.; Zhai, Dongguan; Chen, Daimo
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1547 - 1557
反应条件
hydrogenchloride in water T=0°C;
参考文献
WO2006/39527 A1, ;
Page/Page column 18 ;
反应条件
sodium hydrogencarbonate in THF-H2O
参考文献
Bristol-Myers Squibb Company
Patent: US6605599 B1, 2003 ;
反应条件
sodium hydroxide in methanol; water 3.5 h; Heating; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
sodium hydroxide in 1,4-dioxane; water 18 h;
参考文献
Kaul, Ramesh; Surprenant, Simon; Lubell, William D.
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3838 - 3844
反应条件
1: 92 percent / NaHCO3 / CHCl3; H2O / 1 h / 25 °C 2: 85 percent / NaOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 22 p. 7310 - 7322
反应条件
TEA in 1,4-dioxane; water 24 h; Ambient temperature;
参考文献
Huffman; Gesellchen; Turner; Rothenberger; Osborne; Miller; Chapman; Queener
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1897 - 1914
反应条件
sodium hydroxide in methanol; water Hydrolysis; 3 h; Heating;
参考文献
Guillena; Najera
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7310 - 7322
反应条件
ammonium hydroxide; subtilisin from Bacillus lichenifirmis in water; N,N-dimethyl-formamide T=40°C; pH=8; 3 h; Resolution of racemateEnzymatic reaction;
参考文献
RSC Advances, , vol. 4, # 5 p. 2482 - 2490
